HORDB

ID: hor001950
Uniprot ID: O42143
Protein name: Glucagon-like peptide 1B
Gene name: gcg1
Organism: Xenopus laevis (African clawed frog)
Family: Glucagon family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0050896 response to stimulus
GO CC: GO:0005576 extracellular region

Sequence: HAEGTYTNDVTEYLEEKAAKEFIEWLIKGKP
Length: 31(142-172)
Propeptide: MKSTCYMIGILLMILQNTYQSPVPETDANSRSVKAARNEAVDDSEQLKEVKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRSGELSRRNADYERHAEGTFTSDVTQQLDEKAAKEFIDWLINGGPSKEIISRRNAEFERHAEGTYTNDVTEYLEEKAAKEFIEWLIKGKPKKIRYSRHAEGTFTNDMTNYLEEKAAKEFVGWLIKGRPKRNFSEVHSVEEMDRRHADGSFTNDINKVLDIIAAQEFLDWVINT
Signal peptide: MKSTCYMIGILLMILQNTYQ
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001950_AF2.pdb

hor001950_ESM.pdb

Mass:	414631	Formula:	C165H249N39O52
Absent amino acids:	CMQRS	Common amino acids:	E
pI:	4.5	Basic residues:	5
Polar residues:	8	Hydrophobic residues:	10
Hydrophobicity:	-83.23	Boman Index:	-5473
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	69.35
Instability Index:	1600	Extinction Coefficient cystines:	8480
Absorbance 280nm:	282.67